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KMID : 0360220160570010071
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Journal of the Korean Ophthalmological Society
2016 Volume.57 No. 1 p.71 ~ p.79
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Intravitreal Anti-Vascular Endothelial Growth Factor for Retinal Pigment Epithelial Tear in Retinal Angiomatous Proliferation
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황현지:Hwang Hyun-Ji
장영석:Chang Young-Suk/김종우:Kim Jong-Woo/이태곤:Lee Tae-Gon/김철구:Kim Chul-Gu/조성원:Cho Sung-Won/이동원:Lee Dong-Won/한정일:Han Jung-Il/김재휘:Kim Jae-Hui
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Abstract
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Purpose: To evaluate the treatment outcomes of intravitreal anti-vascular endothelial growth factor (VEGF) therapy for retinal pigment epithelial (RPE) tear in retinal angiomatous proliferation (RAP).
Methods: In the present study we retrospectively analyzed the medical records of 14 patients (14 eyes) diagnosed with RPE tear secondary to RAP treated with intravitreal anti-VEGF. Best-corrected visual acuity (BCVA) when the RPE tear developed was compared with BCVA at 6 months and at the final follow-up.
Results: The mean age of the study patients was 75.1 ± 7.0 years and the mean follow-up period was 23.7 ± 13.7 months. During the follow-up period, patients were treated with a mean of 2.8 ± 1.3 intravitreal anti-VEGF injections. The mean logarithm of minimal angle of resolution BCVA when the RPE tear developed, at 6 months and at the final follow-up was 1.25 ± 0.44, 1.44 ± 0.56, and 1.65 ± 0.39, respectively. The BCVA at 6 months was not different from the baseline value (p = 0.258), whereas the BCVA at the final follow-up was significantly worse than the baseline value (p = 0.002).
Conclusions: The prognosis of RPE tear in RAP is poor despite anti-VEGF therapy. This result suggests further investigations regarding the prevention of RPE tear or more effective treatment method for this condition are necessary.
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KEYWORD
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Age-related macular degeneration, Anti-vascular endothelial growth factor, Retinal angiomatous proliferation, Retinal pigment epithelial tear
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